A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination

Blouin, Jean-Louis; Christie, D. H.; Gos, A.; Lynn, A.; Morris, Michael Andréw; Ledbetter, D. H.; Chakravarti, A.; Antonarakis, Stylianos

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Title		A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination
Authors		Blouin, Jean-Louis Christie, D. H. Gos, A. Lynn, A. Morris, Michael Andréw Ledbetter, D. H. Chakravarti, A. Antonarakis, Stylianos
Published in		American Journal of Human Genetics. 1995, vol. 57, no. 2, p. 388-394
Abstract		We have used a half-YAC containing the human chromosome 21 long-arm telomere to clone, map, and characterize a new dinucleotide repeat polymorphism (D21S1575) close to 21qter. This marker is < 120 kb from the telomeric (TTAGGG)n sequences and is the most distal highly polymorphic marker on chromosome 21q. This marker has a heterozygosity of 71% because of a variable (TA)n repeat embedded within a long interspersed element (LINE) element. Genotyping of the CEPH families and linkage analysis provided a more accurate determination of the full length of the chromosome 21 genetic map. A highly significant difference was detected between male and female recombination rates in the telomeric region: in the most telomeric 2.3 Mb of chromosome 21q, recombination was only observed in male meioses.
Keywords		Base Sequence — Chromosome Mapping — Chromosomes, Human, Pair 21 — Female — Humans — Linkage (Genetics) — Male — Molecular Sequence Data — Polymorphism, Genetic — Recombination, Genetic/ genetics — Repetitive Sequences, Nucleic Acid — Sex Factors — Telomere
Identifiers		PMID: 7668265
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801529/pdf/ajhg00034-0194.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		BLOUIN, Jean-Louis et al. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. In: American Journal of Human Genetics, 1995, vol. 57, n° 2, p. 388-394. https://archive-ouverte.unige.ch/unige:8645