

Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801529/pdf/ajhg00034-0194.pdf
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A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination |
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Authors | ||
Published in | American journal of human genetics. 1995, vol. 57, no. 2, p. 388-394 | |
Abstract | We have used a half-YAC containing the human chromosome 21 long-arm telomere to clone, map, and characterize a new dinucleotide repeat polymorphism (D21S1575) close to 21qter. This marker is < 120 kb from the telomeric (TTAGGG)n sequences and is the most distal highly polymorphic marker on chromosome 21q. This marker has a heterozygosity of 71% because of a variable (TA)n repeat embedded within a long interspersed element (LINE) element. Genotyping of the CEPH families and linkage analysis provided a more accurate determination of the full length of the chromosome 21 genetic map. A highly significant difference was detected between male and female recombination rates in the telomeric region: in the most telomeric 2.3 Mb of chromosome 21q, recombination was only observed in male meioses. | |
Keywords | Base Sequence — Chromosome Mapping — Chromosomes, Human, Pair 21 — Female — Humans — Linkage (Genetics) — Male — Molecular Sequence Data — Polymorphism, Genetic — Recombination, Genetic/ genetics — Repetitive Sequences, Nucleic Acid — Sex Factors — Telomere | |
Identifiers | PMID: 7668265 | |
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![]() ![]() Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801529/pdf/ajhg00034-0194.pdf |
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Citation (ISO format) | BLOUIN, Jean-Louis et al. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. In: American journal of human genetics, 1995, vol. 57, n° 2, p. 388-394. https://archive-ouverte.unige.ch/unige:8645 |