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Scientific article
English

A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination

Published inAmerican journal of human genetics, vol. 57, no. 2, p. 388-394
Publication date1995
Abstract

We have used a half-YAC containing the human chromosome 21 long-arm telomere to clone, map, and characterize a new dinucleotide repeat polymorphism (D21S1575) close to 21qter. This marker is < 120 kb from the telomeric (TTAGGG)n sequences and is the most distal highly polymorphic marker on chromosome 21q. This marker has a heterozygosity of 71% because of a variable (TA)n repeat embedded within a long interspersed element (LINE) element. Genotyping of the CEPH families and linkage analysis provided a more accurate determination of the full length of the chromosome 21 genetic map. A highly significant difference was detected between male and female recombination rates in the telomeric region: in the most telomeric 2.3 Mb of chromosome 21q, recombination was only observed in male meioses.

Keywords
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 21
  • Female
  • Humans
  • Linkage (Genetics)
  • Male
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Recombination, Genetic/ genetics
  • Repetitive Sequences, Nucleic Acid
  • Sex Factors
  • Telomere
Citation (ISO format)
BLOUIN, Jean-Louis et al. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. In: American journal of human genetics, 1995, vol. 57, n° 2, p. 388–394.
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ISSN of the journal0002-9297
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