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Antalgie chez les patients avec une atteinte hépatique

Simonet, Martine Louis
Published in Revue médicale suisse. 2015, vol. 11, no. 480, p. 1380-1384
Abstract The lack of clear recommendations makes optimal pain management difficult in patients with hepatic function impairment. This article reviews the evidence on commonly used analgesics (paracetamol, NSAIDs, opiates). Paracetamol can be safely used at low doses (2-3 grams per day) for a period not exceeding a few days. NSAIDs should be avoided because of their direct hepatic toxicity and an increased risk of life-threatening side-effects (hemorrhagic, renal). Glucuronoconjugated opiates should be preferred but all must be used carefully because of the risk of side effects. Dosage reduction and/or increased dose interval are often required.
Keywords Acetaminophen/therapeutic useAnalgesia/adverse effects/methodsAnalgesics/administration & dosage/adverse effectsAnalgesics, Opioid/therapeutic useAnti-Inflammatory Agents, Non-Steroidal/therapeutic useHumansLiver Diseases/complications/metabolismPain/complications/drug therapy/metabolismPain Management/adverse effects/methods
PMID: 26267943
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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INNAURATO, Giovanni, PIGUET, Valérie, SIMONET, Martine Louis. Antalgie chez les patients avec une atteinte hépatique. In: Revue médicale suisse, 2015, vol. 11, n° 480, p. 1380-1384. https://archive-ouverte.unige.ch/unige:86323

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Deposited on : 2016-08-24

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