en
Scientific article
Open access
English

Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles

Published inNeuron, vol. 89, no. 5, p. 1074-1085
Publication date2016
Abstract

Hippocampal neurons activated during encoding drive the recall of contextual fear memory. Little is known about how such ensembles emerge during acquisition and eventually form the cellular engram. Manipulating the activity of granule cells (GCs) of the dentate gyrus (DG), we reveal a mechanism of lateral inhibition that modulates the size of the cellular engram. GCs engage somatostatin-positive interneurons that inhibit the dendrites of surrounding GCs. Our findings reveal a microcircuit within the DG that controls the size of the cellular engram and the stability of contextual fear memory.

Keywords
  • Action Potentials/genetics
  • Animals
  • Cell Count
  • Cell Size
  • Conditioning (Psychology)/physiology
  • Dentate Gyrus/cytology
  • Fear/physiology
  • Interneurons/physiology
  • Luminescent Proteins/genetics
  • Maze Learning
  • Memory/physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Parvalbumins/genetics/metabolism
  • Patch-Clamp Techniques
  • Rhodopsin/genetics
  • Somatostatin/genetics/metabolism
  • Spatial Behavior/physiology
  • Statistics, Nonparametric
Citation (ISO format)
STEFANELLI, Thomas et al. Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles. In: Neuron, 2016, vol. 89, n° 5, p. 1074–1085. doi: 10.1016/j.neuron.2016.01.024
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0896-6273
532views
186downloads

Technical informations

Creation08/23/2016 2:28:00 PM
First validation08/23/2016 2:28:00 PM
Update time03/15/2023 12:39:30 AM
Status update03/15/2023 12:39:30 AM
Last indexation02/12/2024 12:43:48 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack