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Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles

Published in Neuron. 2016, vol. 89, no. 5, p. 1074-1085
Abstract Hippocampal neurons activated during encoding drive the recall of contextual fear memory. Little is known about how such ensembles emerge during acquisition and eventually form the cellular engram. Manipulating the activity of granule cells (GCs) of the dentate gyrus (DG), we reveal a mechanism of lateral inhibition that modulates the size of the cellular engram. GCs engage somatostatin-positive interneurons that inhibit the dendrites of surrounding GCs. Our findings reveal a microcircuit within the DG that controls the size of the cellular engram and the stability of contextual fear memory.
Keywords Action Potentials/geneticsAnimalsCell CountCell SizeConditioning (Psychology)/physiologyDentate Gyrus/cytologyFear/physiologyInterneurons/physiologyLuminescent Proteins/geneticsMaze LearningMemory/physiologyMiceMice, Inbred C57BLMice, TransgenicParvalbumins/genetics/metabolismPatch-Clamp TechniquesRhodopsin/geneticsSomatostatin/genetics/metabolismSpatial Behavior/physiologyStatistics, Nonparametric
PMID: 26875623
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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STEFANELLI, Thomas et al. Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles. In: Neuron, 2016, vol. 89, n° 5, p. 1074-1085. doi: 10.1016/j.neuron.2016.01.024 https://archive-ouverte.unige.ch/unige:86309

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Deposited on : 2016-08-24

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