Article (Published version) (3.1 MB) - 
Free access
Highlights
Scientific Article
unige:86309 
 |
Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles |
|
| Authors | ||
| Published in | Neuron. 2016, vol. 89, no. 5, p. 1074-1085 | |
| Abstract | Hippocampal neurons activated during encoding drive the recall of contextual fear memory. Little is known about how such ensembles emerge during acquisition and eventually form the cellular engram. Manipulating the activity of granule cells (GCs) of the dentate gyrus (DG), we reveal a mechanism of lateral inhibition that modulates the size of the cellular engram. GCs engage somatostatin-positive interneurons that inhibit the dendrites of surrounding GCs. Our findings reveal a microcircuit within the DG that controls the size of the cellular engram and the stability of contextual fear memory. | |
| Keywords | Action Potentials/genetics — Animals — Cell Count — Cell Size — Conditioning (Psychology)/physiology — Dentate Gyrus/cytology — Fear/physiology — Interneurons/physiology — Luminescent Proteins/genetics — Maze Learning — Memory/physiology — Mice — Mice, Inbred C57BL — Mice, Transgenic — Parvalbumins/genetics/metabolism — Patch-Clamp Techniques — Rhodopsin/genetics — Somatostatin/genetics/metabolism — Spatial Behavior/physiology — Statistics, Nonparametric | |
| Identifiers | PMID: 26875623 | |
| Full text | ||
| Structures | ||
| Research group | Mécanismes cellulaires de la dépendance et de l'addiction (520) | |
| Citation (ISO format) | STEFANELLI, Thomas et al. Hippocampal Somatostatin Interneurons Control the Size of Neuronal Memory Ensembles. In: Neuron, 2016, vol. 89, n° 5, p. 1074-1085. doi: 10.1016/j.neuron.2016.01.024 https://archive-ouverte.unige.ch/unige:86309 |
344 hits 
71 downloads 
Contact an author
Update