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The human sugar-phosphate/phosphate exchanger family SLC37

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Published in Pflügers Archiv. 2004, vol. 447, no. 5, p. 780-783
Abstract The SLC37 family of four predicted proteins is an almost unexplored group of transmembrane sugar transporters. Of the four proteins/genes assigned to date to this family, only one is well known, the SLC37A4 gene (also known as the glucose-6-phosphate transporter 1, G6PT1) mutated in the glycogen storage disease non-1A type. Data on SLC3A1 gene expression are available for humans, while data on SLC37A2 are available for mice. The last SLC37 family member, SLC37A3, is only a putative gene/protein identified by in silico analyses. The four genes are not clustered in a single chromosome as regions and the identity of their predicted polypeptides is between 60 and 20%. Here we propose a new nomenclature for the SLC37 proteins (SPX: sugar- phosphate e xchangers) numbered according to the gene numbering.
Keywords Biological Transport/physiologyCarbohydrate MetabolismHumansMembrane Transport Proteins/chemistry/ physiologyMultigene Family/physiologyPhosphates/ metabolism
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PMID: 12811562
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BARTOLONI, Lucia, ANTONARAKIS, Stylianos. The human sugar-phosphate/phosphate exchanger family SLC37. In: Pflügers Archiv, 2004, vol. 447, n° 5, p. 780-783. https://archive-ouverte.unige.ch/unige:8623

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Deposited on : 2010-07-12

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