UNIGE document Scientific Article
previous document  unige:8608  next document
add to browser collection
Title

The challenge of Down syndrome

Authors
Epstein, C. J.
Published in Trends in Molecular Medicine. 2006, vol. 12, no. 10, p. 473-479
Abstract Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features. The earlier pessimism was due to several reasons, including: (i) the nature of the genetic defect that leads to the syndrome; (ii) the multiplicity of systems involved; and (iii) the high degree of variability of the phenotype. However, science has now caught up with the problem, and recent developments, especially in genetics, genomics, developmental biology and neuroscience, suggest that these potential impediments might not be as arduous as once appeared. As a result, basic research on DS is now rapidly accelerating, and there is hope that the findings will be translatable into benefit for people with DS.
Keywords AnimalsChromosomes, Human, Pair 21/geneticsDisease Models, AnimalDown Syndrome/genetics/ physiopathologyGenetic VariationHumansMultigene Family
Identifiers
PMID: 16935027
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
ANTONARAKIS, Stylianos, EPSTEIN, C. J. The challenge of Down syndrome. In: Trends in Molecular Medicine, 2006, vol. 12, n° 10, p. 473-479. https://archive-ouverte.unige.ch/unige:8608

177 hits

0 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :