Mendelian disorders and multifactorial traits: the big divide or one for all?

Antonarakis, Stylianos; Chakravarti, Aravinda; Cohen, J. C.; Hardy, John

doi:10.1038/nrg2793

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Title		Mendelian disorders and multifactorial traits: the big divide or one for all?
Authors		Antonarakis, Stylianos Chakravarti, Aravinda Cohen, J. C. Hardy, John
Published in		Nature Reviews Genetics. 2010, vol. 11, no. 5, p. 380-384
Abstract		For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
Keywords		Animals — Disease/ genetics — Genetic Predisposition to Disease — Genome, Human — Genome-Wide Association Study — Humans — Multifactorial Inheritance
Identifiers		DOI: 10.1038/nrg2793 PMID: 20395971
Full text		Article - Limited access to UNIGE Other version: http://www.nature.com/nrg/journal/v11/n5/pdf/nrg2793.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
Citation (ISO format)		ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all?. In: Nature Reviews Genetics, 2010, vol. 11, n° 5, p. 380-384. doi: 10.1038/nrg2793 https://archive-ouverte.unige.ch/unige:8607