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Mendelian disorders and multifactorial traits: the big divide or one for all?

Chakravarti, Aravinda
Cohen, J. C.
Hardy, John
Published in Nature reviews. Genetics. 2010, vol. 11, no. 5, p. 380-384
Abstract For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
Keywords AnimalsDisease/ geneticsGenetic Predisposition to DiseaseGenome, HumanGenome-Wide Association StudyHumansMultifactorial Inheritance
PMID: 20395971
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Other version: http://www.nature.com/nrg/journal/v11/n5/pdf/nrg2793.pdf
Research group Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
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ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all?. In: Nature reviews. Genetics, 2010, vol. 11, n° 5, p. 380-384. doi: 10.1038/nrg2793 https://archive-ouverte.unige.ch/unige:8607

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Deposited on : 2010-07-12

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