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Scientific Article
unige:8607 
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Mendelian disorders and multifactorial traits: the big divide or one for all? |
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| Authors | ||
| Published in | Nature Reviews Genetics. 2010, vol. 11, no. 5, p. 380-384 | |
| Abstract | For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences. | |
| Keywords | Animals — Disease/ genetics — Genetic Predisposition to Disease — Genome, Human — Genome-Wide Association Study — Humans — Multifactorial Inheritance | |
| Identifiers | DOI: 10.1038/nrg2793 PMID: 20395971 | |
| Full text |
Article - Limited access to UNIGE Other version: http://www.nature.com/nrg/journal/v11/n5/pdf/nrg2793.pdf |
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| Structures | ||
| Research group | Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248) | |
| Citation (ISO format) | ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all?. In: Nature Reviews Genetics, 2010, vol. 11, n° 5, p. 380-384. https://archive-ouverte.unige.ch/unige:8607 |
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