Article - Limited access to UNIGE
Other version: http://www.nature.com/nrg/journal/v11/n5/pdf/nrg2793.pdf
Mendelian disorders and multifactorial traits: the big divide or one for all?
|Published in||Nature Reviews Genetics. 2010, vol. 11, no. 5, p. 380-384|
|Abstract||For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.|
|Keywords||Animals — Disease/ genetics — Genetic Predisposition to Disease — Genome, Human — Genome-Wide Association Study — Humans — Multifactorial Inheritance|
|Research group||Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)|
|ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all?. In: Nature Reviews Genetics, 2010, vol. 11, n° 5, p. 380-384. https://archive-ouverte.unige.ch/unige:8607|