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Scientific article
English

Mendelian disorders and multifactorial traits: the big divide or one for all?

Published inNature reviews. Genetics, vol. 11, no. 5, p. 380-384
Publication date2010
Abstract

For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.

Keywords
  • Animals
  • Disease/ genetics
  • Genetic Predisposition to Disease
  • Genome, Human
  • Genome-Wide Association Study
  • Humans
  • Multifactorial Inheritance
Citation (ISO format)
ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all? In: Nature reviews. Genetics, 2010, vol. 11, n° 5, p. 380–384. doi: 10.1038/nrg2793
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ISSN of the journal1471-0056
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