Mendelian disorders and multifactorial traits: the big divide or one for all?

Antonarakis, Stylianos; Chakravarti, Aravinda; Cohen, J. C.; Hardy, John

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Title		Mendelian disorders and multifactorial traits: the big divide or one for all?
Authors		Antonarakis, Stylianos Chakravarti, Aravinda Cohen, J. C. Hardy, John
Published in		Nature Reviews Genetics. 2010, vol. 11, no. 5, p. 380-384
Abstract		For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
Keywords		Animals — Disease/ genetics — Genetic Predisposition to Disease — Genome, Human — Genome-Wide Association Study — Humans — Multifactorial Inheritance
Identifiers		DOI: 10.1038/nrg2793 PMID: 20395971
Full text		Article - Limited access to UNIGE Other version: http://www.nature.com/nrg/journal/v11/n5/pdf/nrg2793.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group		Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
Citation (ISO format)		ANTONARAKIS, Stylianos et al. Mendelian disorders and multifactorial traits: the big divide or one for all?. In: Nature Reviews Genetics, 2010, vol. 11, n° 5, p. 380-384. https://archive-ouverte.unige.ch/unige:8607