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Title

Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

Authors
Lasseter, V. K.
Radhakrishna, U.
Nestadt, G.
Housman, D. E.
Kazazian, H. H.
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Published in American Journal of Medical Genetics. 1999, vol. 88, no. 4, p. 348-351
Abstract To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with this disease. Parametric and nonparametric linkage analysis did not provide evidence for linkage between KCNN3 (that we mapped to chromosome 1q21) and schizophrenia. Furthermore, we observed no difference in the distribution of the (CAG)n alleles between affected and normal individuals. These results do not support the hypothesis that larger KCNN3 alleles are preferentially associated with schizophrenia [Chandy et al. 1998 Mol Psychiatr 3:32-37] in individuals from multiply affected families.
Keywords Chromosome MappingChromosomes, Human, Pair 1FemaleGenetic MarkersGenotypeHumansLinkage (Genetics)MalePolymorphism, GeneticPotassium Channels/ geneticsPotassium Channels, Calcium-ActivatedSchizophrenia/ geneticsSmall-Conductance Calcium-Activated Potassium ChannelsTrinucleotide Repeats
Identifiers
PMID: 10402501
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ANTONARAKIS, Stylianos et al. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. In: American Journal of Medical Genetics, 1999, vol. 88, n° 4, p. 348-351. https://archive-ouverte.unige.ch/unige:8605

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Deposited on : 2010-07-12

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