Scientific article

Chromosome 21: from sequence to applications

Published inCurrent opinion in genetics & development, vol. 11, no. 3, p. 241-246
Publication date2001

Last year we celebrated the sequencing of the entire long arm of human chromosome 21. This achievement now provides unprecedented opportunities to understand the molecular pathophysiology of trisomy 21, elucidate the mechanisms of all monogenic disorders of chromosome 21, and discover genes and functional sequence variations that predispose to common complex disorders. All these steps require the functional analysis of gene products and the determination of the sequence variation of this chromosome.

  • Animals
  • Chromosomes, Human, Pair 21
  • Disease Models, Animal
  • Down Syndrome/genetics
  • Genetic Variation
  • Humans
  • Mice
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA
Citation (ISO format)
ANTONARAKIS, Stylianos. Chromosome 21: from sequence to applications. In: Current opinion in genetics & development, 2001, vol. 11, n° 3, p. 241–246.
Updates (1)
ISSN of the journal0959-437X

Technical informations

Creation07/12/2010 11:56:48 AM
First validation07/12/2010 11:56:48 AM
Update time03/14/2023 3:49:56 PM
Status update03/14/2023 3:49:56 PM
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