The selective amobarbital test in the anterior choroidal artery: perfusion pattern assessed by intraarterial SPECT and prediction of postoperative verbal memory

Vulliemoz, Serge; Pegna, Alan; Annoni, Gian-Maria; Yilmaz, Hasan; Willi, Jean-Pierre; Spinelli, Laurent Jean-François; Landis, Theodor; Seeck, Margitta

doi:10.1016/j.yebeh.2007.11.015

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Title		The selective amobarbital test in the anterior choroidal artery: perfusion pattern assessed by intraarterial SPECT and prediction of postoperative verbal memory
Authors		Vulliemoz, Serge Pegna, Alan Annoni, Gian-Maria Yilmaz, Hasan Willi, Jean-Pierre Spinelli, Laurent Jean-François Landis, Theodor Seeck, Margitta
Published in		Epilepsy & Behavior. 2008, vol. 12, no. 3, p. 445-55
Abstract		To screen for patients at risk for memory decline after temporal lobe epilepsy (TLE) surgery, selective amobarbital procedures, such as injection into the anterior choroidal artery (ACA-IAT), are sometimes used. We investigated the extent of the territory affected during ACA-IAT and its predictive value with respect to postoperative memory. Seventeen patients with TLE underwent ACA-IAT. In 9 of 17 patients, intraarterial SPECT co-registrated to MRI allowed delineation of amobarbital-perfused structures. Another subgroup of 9 of 17 patients underwent anterior temporal lobectomy. Verbal memory was tested pre- and postoperatively and during ACA-IAT. Major variations in the ACA-IAT perfusion pattern occurred and were not correlated with the verbal memory scores during ACA-IAT. Postoperatively, no patient experienced a severe verbal memory decline, but individual postoperative performance was not correlated with results during ACA-IAT. Our study suggests that ACA-IAT can be used to screen for severe postoperative amnesia in inconclusive cases, but cannot predict individual outcome, even when the perfusion pattern is taken into account.
Keywords		Adolescent — Adult — Amobarbital/administration & dosage — Anterior Temporal Lobectomy/methods — Carotid Artery Internal — Electroencephalography — Epilepsy — Temporal Lobe/physiopathology/radionuclide imaging/surgery — Evaluation Studies as Topic — Female — Functional Laterality/drug effects/physiology — Humans — Hypnotics and Sedatives/administration & dosage — Magnetic Resonance Imaging — Male — Memory/drug effects/physiology — Middle Aged — Neuropsychological Tests — Postoperative Period — Predictive Value of Tests — Retrospective Studies — Tomography Emission-Computed Single-Photon — Verbal Learning/drug effects/physiology
Identifiers		DOI: 10.1016/j.yebeh.2007.11.015 PMID: 18248852
Full text		Article (Accepted version) (531 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de psychologie et des sciences de l'éducation / Section de psychologie
Research groups		Epilepsie et Chirurgie (149) Neuropsychologie clinique appliquée et neurosciences cognitives (703)
Citation (ISO format)		VULLIEMOZ, Serge et al. The selective amobarbital test in the anterior choroidal artery: perfusion pattern assessed by intraarterial SPECT and prediction of postoperative verbal memory. In: Epilepsy & Behavior, 2008, vol. 12, n° 3, p. 445-55. doi: 10.1016/j.yebeh.2007.11.015 https://archive-ouverte.unige.ch/unige:860

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The selective amobarbital test in the anterior choroidal artery: perfusion pattern assessed by intraarterial SPECT and prediction of postoperative verbal memory