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Scientific article
English

Isolation and initial characterization of the mouse Dnmt3l gene

Published inCytogenetics and cell genetics, vol. 92, no. 1-2, p. 122-126
Publication date2001
Abstract

We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cytosine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarity to members of the DNMT3/Dnmt3 family. The Dnmt3l protein contains an ADD zinc finger, which Dnmt3l shares with other Dnmt3 family members and Atrx. RT-PCR analysis showed Dnmt3l expression in testis, thymus, ovary, and heart, as well as in 7-day, 15-day, and 17-day mouse embryos.

Keywords
  • Amino Acid Sequence
  • Animals
  • COS Cells
  • DNA (Cytosine-5-)-Methyltransferase/analysis/chemistry/ genetics
  • Embryo, Mammalian/enzymology
  • Exons/genetics
  • Expressed Sequence Tags
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Ovary/enzymology
  • Physical Chromosome Mapping
  • Polymorphism, Single Nucleotide/genetics
  • Protein Structure, Tertiary
  • RNA, Messenger/analysis/genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Testis/enzymology
  • Thymus Gland/enzymology
  • Zinc Fingers
Citation (ISO format)
AAPOLA, Ulla et al. Isolation and initial characterization of the mouse Dnmt3l gene. In: Cytogenetics and cell genetics, 2001, vol. 92, n° 1-2, p. 122–126.
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ISSN of the journal0301-0171
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