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Titles listNovel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides)
Titles listNovel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides)
Scientific Article
unige:85452 
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Novel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides) |
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| Published in | International Journal of Pharmaceutics. 2006, vol. 319, no. 1-2, p. 147-154 | |
| Abstract | Novel amphiphilic methoxy-poly(ethylene glycol)-poly(hexyl-substituted lactides) block copolymers were synthesized by ring-opening polymerization (ROP) of mono and dihexyl-substituted lactide (mHLA and diHLA) in bulk at 100 degrees C in the presence of tin(II) 2-ethylhexanoate (Sn(Oct)(2)) as catalyst and methoxy-poly(ethylene glycol) (MPEG) as initiator. MPEG-PmHLA and MPEG-PdiHLA copolymers of predictable molecular weights and narrow polydispersities were obtained, as shown by (1)H NMR and GPC. DSC experiments showed that the MPEG-PHLA block-copolymer presents a bulk microstructure containing MPEG domains segregated from the PHLA domains. Micelles were successfully prepared from these block copolymers, with sizes ranging from 30 to 80 nm. The critical micellar concentration (CMC) was found to decrease with the increasing number of hexyl groups on the polyester block (MPEG-PLA > MPEG-PmHLA > MPEG-PdiHLA) for copolymers of the same composition and molecular weight. The hydrophobicity of the micelle core in dependence of the number of hexyl groups along the PLA chain was evidenced by absorbance experiments with the incorporation of the dye Nile Red. These novel amphiphilic copolymers are interesting for micellar drug delivery and especially in regard to optimized hydrophobic drug loadings, as it was shown for griseofulvin as a model drug. | |
| Keywords | Micelles — Drug delivery — Substituted poly(lactides) — Poly(ethylene glycol) — Biodegradable polymers — Biocompatible polymers — Hydrophobic drugs — Nile Red — Griseofulvin | |
| Identifiers | PMID: 16713691 | |
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| Citation (ISO format) | TRIMAILLE, Thomas et al. Novel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides). In: International Journal of Pharmaceutics, 2006, vol. 319, n° 1-2, p. 147-154. doi: 10.1016/j.ijpharm.2006.03.036 https://archive-ouverte.unige.ch/unige:85452 |
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