Connexins and their channels in inflammation

Willebrords, Joost; Crespo Yanguas, Sara; Maes, Michaël; Decrock, Elke; Wang, Nan; Leybaert, Luc; Kwak, Brenda; Green, Colin R; Cogliati, Bruno; Vinken, Mathieu

doi:10.1080/10409238.2016.1204980

Scientific article

English

Connexins and their channels in inflammation

Contributors

Willebrords, Joost; Crespo Yanguas, Sara; Maes, Michaël; Decrock, Elke; Wang, Nan; Leybaert, Luc; Kwak, Brenda

; Green, Colin R; Cogliati, Bruno; Vinken, Mathieu

Published in

Critical reviews in biochemistry and molecular biology, p. 1-27

Publication date

2016

Abstract

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration. Despite the wealth of knowledge regarding the involvement of cellular communication in inflammation, studies on the role of connexin-based channels in this process have only begun to emerge in the last few years. In this paper, a state-of-the-art overview of the effects of inflammation on connexin signaling is provided. Vice versa, the involvement of connexins and their channels in inflammation will be discussed by relying on studies that use a variety of experimental tools, such as genetically modified animals, small interfering RNA and connexin-based channel blockers. A better understanding of the importance of connexin signaling in inflammation may open up towards clinical perspectives.

UNIGE affiliation entities

UNIGE research groups

Connexines et pathologies cardiovasculaires (665)

Citation (ISO format)

WILLEBRORDS, Joost et al. Connexins and their channels in inflammation. In: Critical reviews in biochemistry and molecular biology, 2016, p. 1–27. doi: 10.1080/10409238.2016.1204980

Article (Published version)

Identifiers

PID : unige:85402
DOI : 10.1080/10409238.2016.1204980
PMID : 27387655

Journal ISSN

1040-9238

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21/07/2016 08:49:00

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21/07/2016 08:49:00

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13/10/2025 20:48:19

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02/04/2025 07:08:12

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22/07/2026 10:55:20

Connexins and their channels in inflammation

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Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Creation

First validation

Update

Status update

Last indexation