UNIGE document Scientific Article
previous document  unige:85399  next document
add to browser collection
Title

Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size

Authors
Published in International Journal of Pharmaceutics. 1992, vol. 87, no. 1-3, p. 247-253
Abstract Polymeric nanoparticles were prepared as aqueous dispersions using an emulsion technique involving a salting-out process which avoids surfactants and chlorinated solvents. The preparation method consists of adding an electrolyte-saturated or a nonelectrolyte-saturated aqueous solution containing poly(vinyl alcohol) (PVAL) as a viscosity-increasing agent and stabilizer to an acetone solution of polymer under continuous stirring. The saturated aqueous solution prevents acetone from mixing with water by a salting-out process. After the preparation of an oil-in-water emulsion, water is added in a sufficient amount to allow complete diffusion of acetone into the aqueous phase, inducing the formation of nanospheres. Several manufacturing parameters were varied: stirring rate, internal/external phase ratio, concentration of polymer in the acetone phase, type of electrolyte, concentration and type of PVAL in the aqueous phase.
Keywords NanoparticleLatexPolymeric aqueous dispersionSalting-outMethacrylic acid copolymerPoly(dl-lactic acid)Ethylcellulose
Identifiers
Full text
Structures
Research group Technologie pharmaceutique
Citation
(ISO format)
ALLÉMANN, Eric, GURNY, Robert, DOELKER, Eric. Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. In: International Journal of Pharmaceutics, 1992, vol. 87, n° 1-3, p. 247-253. https://archive-ouverte.unige.ch/unige:85399

97 hits

1 download

Update

Deposited on : 2016-07-21

Export document
Format :
Citation style :