UNIGE document Scientific Article
previous document  unige:85330  next document
add to browser collection

T-bet and Eomesodermin in NK Cell Development, Maturation, and Function

Simonetta, Federico
Published in Frontiers in Immunology. 2016, vol. 7, p. 241
Abstract Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.
PMID: 27379101
Full text
Article (Published version) (581 Kb) - public document Free access
Research groups Groupe Roosnek Eddy (hémato-oncologie) (19)
Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
(ISO format)
SIMONETTA, Federico, PRADIER, Amandine, ROOSNEK, Eddy Emile. T-bet and Eomesodermin in NK Cell Development, Maturation, and Function. In: Frontiers in Immunology, 2016, vol. 7, p. 241. doi: 10.3389/fimmu.2016.00241 https://archive-ouverte.unige.ch/unige:85330

343 hits



Deposited on : 2016-07-19

Export document
Format :
Citation style :