en
Scientific article
Open access
English

T-bet and Eomesodermin in NK Cell Development, Maturation, and Function

Published inFrontiers in immunology, vol. 7, 241
Publication date2016
Abstract

Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.

Citation (ISO format)
SIMONETTA, Federico, PRADIER, Amandine, ROOSNEK, Eddy Emile. T-bet and Eomesodermin in NK Cell Development, Maturation, and Function. In: Frontiers in immunology, 2016, vol. 7, p. 241. doi: 10.3389/fimmu.2016.00241
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1664-3224
468views
202downloads

Technical informations

Creation2016/07/19 10:34:00
First validation2016/07/19 10:34:00
Update time2023/03/15 00:33:33
Status update2023/03/15 00:33:33
Last indexation2024/01/16 21:19:16
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack