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Scientific Article
unige:85330 
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T-bet and Eomesodermin in NK Cell Development, Maturation, and Function |
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| Published in | Frontiers in immunology. 2016, vol. 7, 241 | |
| Abstract | Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions. | |
| Identifiers | PMID: 27379101 | |
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| Research groups | Groupe Roosnek Eddy (hémato-oncologie) (19) Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982) | |
| Citation (ISO format) | SIMONETTA, Federico, PRADIER, Amandine, ROOSNEK, Eddy Emile. T-bet and Eomesodermin in NK Cell Development, Maturation, and Function. In: Frontiers in immunology, 2016, vol. 7, p. 241. doi: 10.3389/fimmu.2016.00241 https://archive-ouverte.unige.ch/unige:85330 |
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