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T-bet and Eomesodermin in NK Cell Development, Maturation, and Function

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Published in Frontiers in Immunology. 2016, vol. 7, p. 241
Abstract Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.
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PMID: 27379101
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Article (Published version) (581 Kb) - public document Free access
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Research group Groupe Roosnek Eddy (hémato-oncologie) (19)
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SIMONETTA, Federico, PRADIER, Amandine, ROOSNEK, Eddy Emile. T-bet and Eomesodermin in NK Cell Development, Maturation, and Function. In: Frontiers in Immunology, 2016, vol. 7, p. 241. https://archive-ouverte.unige.ch/unige:85330

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Deposited on : 2016-07-19

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