Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

Allémann, Eric; Rousseau, Jacques; Brasseur, Nicole; Kudrevich, Svetlana V.; Lewis, Karina; van Lier, Johan E.

doi:10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5

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Title		Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles
Authors		Allémann, Eric Rousseau, Jacques Brasseur, Nicole Kudrevich, Svetlana V. Lewis, Karina van Lier, Johan E.
Published in		International Journal of Cancer. 1996, vol. 66, no. 6, p. 821-824
Abstract		Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.
Keywords		Animals — Biodegradation — Environmental — Coloring Agents/administration & dosage/pharmacokinetics/therapeutic use — Drug Carriers — Emulsions — Glycerol/analogs & derivatives — Indoles/administration & dosage/pharmacokinetics/therapeutic use — Lactates — Lactic Acid — Male — Mammary Neoplasms — Experimental/drug therapy/pathology — Mice — Inbred BALB C — Microspheres — Neoplasm Transplantation — Organometallic Compounds/administration & dosage/pharmacokinetics/therapeutic use — Particle Size — Photochemotherapy — Polyethylene Glycols — Polymers — Radiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic use — Solubility — Suspensions — Thigh — Tumor Cells — Cultured
Identifiers		DOI: 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5 PMID: 8647656
Full text		Article (Published version) (435 Kb) - Limited access to UNIGE
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Research group		Technologie pharmaceutique
Citation (ISO format)		ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International Journal of Cancer, 1996, vol. 66, n° 6, p. 821-824. doi: 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5 https://archive-ouverte.unige.ch/unige:85320

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Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles