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Scientific article
English

Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

Published inInternational journal of cancer, vol. 66, no. 6, p. 821-824
Publication date1996
Abstract

Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.

Keywords
  • Animals
  • Biodegradation
  • Environmental
  • Coloring Agents/administration & dosage/pharmacokinetics/therapeutic use
  • Drug Carriers
  • Emulsions
  • Glycerol/analogs & derivatives
  • Indoles/administration & dosage/pharmacokinetics/therapeutic use
  • Lactates
  • Lactic Acid
  • Male
  • Mammary Neoplasms
  • Experimental/drug therapy/pathology
  • Mice
  • Inbred BALB C
  • Microspheres
  • Neoplasm Transplantation
  • Organometallic Compounds/administration & dosage/pharmacokinetics/therapeutic use
  • Particle Size
  • Photochemotherapy
  • Polyethylene Glycols
  • Polymers
  • Radiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic use
  • Solubility
  • Suspensions
  • Thigh
  • Tumor Cells
  • Cultured
Citation (ISO format)
ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International journal of cancer, 1996, vol. 66, n° 6, p. 821–824. doi: 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5
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Article (Published version)
accessLevelRestricted
ISSN of the journal0020-7136
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