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Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles |
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Published in | International Journal of Cancer. 1996, vol. 66, no. 6, p. 821-824 | |
Abstract | Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT. | |
Keywords | Animals — Biodegradation — Environmental — Coloring Agents/administration & dosage/pharmacokinetics/therapeutic use — Drug Carriers — Emulsions — Glycerol/analogs & derivatives — Indoles/administration & dosage/pharmacokinetics/therapeutic use — Lactates — Lactic Acid — Male — Mammary Neoplasms — Experimental/drug therapy/pathology — Mice — Inbred BALB C — Microspheres — Neoplasm Transplantation — Organometallic Compounds/administration & dosage/pharmacokinetics/therapeutic use — Particle Size — Photochemotherapy — Polyethylene Glycols — Polymers — Radiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic use — Solubility — Suspensions — Thigh — Tumor Cells — Cultured | |
Identifiers | PMID: 8647656 | |
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Research group | Technologie pharmaceutique | |
Citation (ISO format) | ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International Journal of Cancer, 1996, vol. 66, n° 6, p. 821-824. doi: 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5 https://archive-ouverte.unige.ch/unige:85320 |