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Title

Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles
Authors
Allémann, Eric
Rousseau, Jacques
Brasseur, Nicole
Kudrevich, Svetlana V.
Lewis, Karina
van Lier, Johan E.
Published in International Journal of Cancer. 1996, vol. 66, no. 6, p. 821-824
Abstract Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.
Keywords Animals — Biodegradation — Environmental — Coloring Agents/administration & dosage/pharmacokinetics/therapeutic use — Drug Carriers — Emulsions — Glycerol/analogs & derivatives — Indoles/administration & dosage/pharmacokinetics/therapeutic use — Lactates — Lactic Acid — Male — Mammary Neoplasms — Experimental/drug therapy/pathology — Mice — Inbred BALB C — Microspheres — Neoplasm Transplantation — Organometallic Compounds/administration & dosage/pharmacokinetics/therapeutic use — Particle Size — Photochemotherapy — Polyethylene Glycols — Polymers — Radiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic use — Solubility — Suspensions — Thigh — Tumor Cells — Cultured
Identifiers
PMID: 8647656
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Article (Published version) (435 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Research group Technologie pharmaceutique
Citation
(ISO format) 		ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International Journal of Cancer, 1996, vol. 66, n° 6, p. 821-824. https://archive-ouverte.unige.ch/unige:85320

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Deposited on : 2016-07-19

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