Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

Allémann, Eric; Rousseau, Jacques; Brasseur, Nicole; Kudrevich, Svetlana V.; Lewis, Karina; van Lier, Johan E.

doi:10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5

Scientific article

English

Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

ContributorsAllémann, Eric

; Rousseau, Jacques; Brasseur, Nicole; Kudrevich, Svetlana V.; Lewis, Karina; van Lier, Johan E.

Published inInternational journal of cancer, vol. 66, no. 6, p. 821-824

Publication date1996

Abstract

Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.

Keywords

Animals
Biodegradation
Environmental
Coloring Agents/administration & dosage/pharmacokinetics/therapeutic use
Drug Carriers
Emulsions
Glycerol/analogs & derivatives
Indoles/administration & dosage/pharmacokinetics/therapeutic use
Lactates
Lactic Acid
Male
Mammary Neoplasms
Experimental/drug therapy/pathology
Mice
Inbred BALB C
Microspheres
Neoplasm Transplantation
Organometallic Compounds/administration & dosage/pharmacokinetics/therapeutic use
Particle Size
Photochemotherapy
Polyethylene Glycols
Polymers
Radiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic use
Solubility
Suspensions
Thigh
Tumor Cells
Cultured

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Research groups

Technologie pharmaceutique

Citation (ISO format)

ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International journal of cancer, 1996, vol. 66, n° 6, p. 821–824. doi: 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5

Article (Published version)

Identifiers

PID : unige:85320
DOI : 10.1002/(SICI)1097-0215(19960611)66:6<821::AID-IJC19>3.0.CO;2-5
PMID : 8647656

Journal ISSN0020-7136

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Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

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