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Title

Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles

Authors
Rousseau, Jacques
Brasseur, Nicole
Kudrevich, Svetlana V.
Lewis, Karina
van Lier, Johan E.
Published in International Journal of Cancer. 1996, vol. 66, no. 6, p. 821-824
Abstract Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second-generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coated PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT.
Keywords AnimalsBiodegradationEnvironmentalColoring Agents/administration & dosage/pharmacokinetics/therapeutic useDrug CarriersEmulsionsGlycerol/analogs & derivativesIndoles/administration & dosage/pharmacokinetics/therapeutic useLactatesLactic AcidMaleMammary NeoplasmsExperimental/drug therapy/pathologyMiceMiceInbred BALB CMicrospheresNeoplasm TransplantationOrganometallic Compounds/administration & dosage/pharmacokinetics/therapeutic useParticle SizePhotochemotherapyPolyethylene GlycolsPolymersRadiation-Sensitizing Agents/administration & dosage/pharmacokinetics/therapeutic useSolubilitySuspensionsThighTumor CellsCultured
Identifiers
PMID: 8647656
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ALLÉMANN, Eric et al. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles. In: International Journal of Cancer, 1996, vol. 66, n° 6, p. 821-824. https://archive-ouverte.unige.ch/unige:85320

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