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Aqueous nanodispersions prepared by a salting-out process

Bindschaedler, Christian
Published in International Journal of Pharmaceutics. 1992, vol. 87, no. 1-3, p. 239-246
Abstract Cellulose acetate phthalate nanodispersions were prepared in the form of a redispersible powder by a new preparation technique based on the salting-out process between two miscible solvents. This method involved the selection of salts producing the salting-out of acetone from water. Poly(vinyl alcohol) was used as protective colloid during the particle formation step and in the finished product. For a pharmaceutical use, the advantage of this new technique is that the process does not require any surfactant or increase in temperature and thus may be useful for biopolymers or heat-sensitive substances. These nanodispersions may also be dried by lyophilization and the particles subsequently redispersed in an aqueous medium before use.
Keywords Cellulose acetate phthalateLatexNanodispersionNanoparticleSalting-outPhase separation
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IBRAHIM KHALIL, Houssam Marc et al. Aqueous nanodispersions prepared by a salting-out process. In: International Journal of Pharmaceutics, 1992, vol. 87, n° 1-3, p. 239-246. https://archive-ouverte.unige.ch/unige:85317

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