Scientific article
English

Aqueous nanodispersions prepared by a salting-out process

Published inInternational journal of pharmaceutics, vol. 87, no. 1-3, p. 239-246
Publication date1992
Abstract

Cellulose acetate phthalate nanodispersions were prepared in the form of a redispersible powder by a new preparation technique based on the salting-out process between two miscible solvents. This method involved the selection of salts producing the salting-out of acetone from water. Poly(vinyl alcohol) was used as protective colloid during the particle formation step and in the finished product. For a pharmaceutical use, the advantage of this new technique is that the process does not require any surfactant or increase in temperature and thus may be useful for biopolymers or heat-sensitive substances. These nanodispersions may also be dried by lyophilization and the particles subsequently redispersed in an aqueous medium before use.

Keywords
  • Cellulose acetate phthalate
  • Latex
  • Nanodispersion
  • Nanoparticle
  • Salting-out
  • Phase separation
Citation (ISO format)
IBRAHIM KHALIL, Houssam Marc et al. Aqueous nanodispersions prepared by a salting-out process. In: International journal of pharmaceutics, 1992, vol. 87, n° 1-3, p. 239–246. doi: 10.1016/0378-5173(92)90248-Z
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0378-5173
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