Evaluation of the transepidermal permeation of diethylene glycol monoethyl ether and skin water loss

Ganem-Quintanar, A.; Lafforgue, C.; Falson-Rieg, F.; Buri, Pierre

doi:10.1016/S0378-5173(96)04809-0

Scientific article

English

Evaluation of the transepidermal permeation of diethylene glycol monoethyl ether and skin water loss

Contributors

Ganem-Quintanar, A.; Lafforgue, C.; Falson-Rieg, F.; Buri, Pierre

Published in

International journal of pharmaceutics, vol. 147, no. 2, p. 165-171

Publication date

1997

Abstract

The rate of Transcutol® (TC)-water interchange, was studied using whole and stripped hairless rat skin in a modified vertical Franz diffusion cell. The presence of stratum corneum limited the passage of the two solvents, but after stripping of the skin, the rate of TC transfer increased and the water flow rose until the vapour pressure at the skin surface and in the ambient air was similar. The results suggest that TC increased the donor hydration by increasing the outflow of water, with a change in the donor composition. These two opposite fluxes and the alteration of the bulk constitution of the skin and of the donor compartment throughout the experiment, are important factors to be considered for the permeation studies with this solvent.

Keywords

Skin absorption
Penetration enhancer
Epidermal water loss
Diethylene glycol monoethyl ether

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

GANEM-QUINTANAR, A. et al. Evaluation of the transepidermal permeation of diethylene glycol monoethyl ether and skin water loss. In: International journal of pharmaceutics, 1997, vol. 147, n° 2, p. 165–171. doi: 10.1016/S0378-5173(96)04809-0

Article (Published version)

Identifiers

PID : unige:85285
DOI : 10.1016/S0378-5173(96)04809-0

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S0378517396048090

Journal ISSN

0378-5173

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Creation

06/07/2016 16:34:00

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06/07/2016 16:34:00

Update

15/03/2023 00:33:08

Status update

15/03/2023 00:33:07

Last indexation

31/10/2024 03:57:45

Evaluation of the transepidermal permeation of diethylene glycol monoethyl ether and skin water loss

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation