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Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer

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Published in International Journal of Pharmaceutics. 2006, vol. 326, no. 1-2, p. 174-181
Abstract A photodynamic approach has been suggested to improve diagnosis and therapy of ovarian cancer. As Hypericin (Hy), a natural photosensitizer (PS) extracted from Hypericum perforatum, has been shown to be efficient in vitro and in vivo for the detection or treatment of other cancers, Hy could also be a potent tool for the treatment and detection of ovarian cancer. Due to its hydrophobicity, systemic administration of Hy is problematic. Thus, polymeric nanoparticles (NPs) of polylactic acid (PLA) or polylactic-co-glycolic acid (PLGA) were used as a drug delivery system. Hy-loaded NPs were produced with the following characteristics: (i) size in the 200-300 nm range, (ii) negative zeta potential, (iii) low residual PVAL and (iv) drug loading from 0.03 to 0.15% (w/w). Their in vitro photoactivity was investigated on the NuTu-19 ovarian cancer cell model derived from Fischer 344 rats and compared to free drug. Hy-loaded PLA NPs exhibited a higher photoactivity than free drug. Increasing light dose or incubation time with cells induced an enhanced activity of Hy-loaded PLA NPs. Increased NP drug loading had a negative effect on their photoactivity on NuTu-19 cells: at the same Hy concentration, the higher was the drug loading, the lower was the phototoxic effect. The influence of NP drug loading on the Hy release from NPs was also investigated.
Keywords Photodynamic therapyBiodegradable nanoparticlesHypericinOvarian cancerIn vitroDrug delivery system
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PMID: 16930882
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ZEISSER-LABOUEBE, Magali et al. Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer. In: International Journal of Pharmaceutics, 2006, vol. 326, n° 1-2, p. 174-181. https://archive-ouverte.unige.ch/unige:85066

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Deposited on : 2016-07-06

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