UNIGE document Scientific Article
previous document  unige:84992  next document
add to browser collection
Title

In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use

Authors
Nguyen-Xuan, T.
Ionescu, E.
Ravelli, G.P.
Buri, P.
Published in European Journal of Pharmaceutics and Biopharmaceutics. 1997, vol. 43, no. 1, p. 59-63
Abstract Two types of mucoadhesive semi-solid formulations (hydrophilic and hydrophobic) for the treatment of mucositises, stomatitises and aphtae were investigated in healthy human volunteers using a gamma scintigraphic technique. The investigations showed that the clearance of hydrophobic formulations follows zero order kinetics whereas the hydrophilic formulation follows a biphasic elimination pattern. All formulations showed an acceptable tolerance but the subjects' preference went clearly to the hydrophobic formulations. Hydrophobic formulations maintained their adhesive and cohesive properties throughout the test period, loosing less than 10% activity within the first hour, whereas about 50% of the mucoadhesive hydrophilic preparation was eliminated within the same time period.
Keywords AphtaeBioadhesionBuccal mucosaGamma scintigraphyIn vivo evaluationLidocaineSemi-solid formulationsSucralfate
Identifiers
Full text
Structures
Citation
(ISO format)
JACQUES, Yves Rémi Albert et al. In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use. In: European Journal of Pharmaceutics and Biopharmaceutics, 1997, vol. 43, n° 1, p. 59-63. https://archive-ouverte.unige.ch/unige:84992

76 hits

1 download

Update

Deposited on : 2016-07-04

Export document
Format :
Citation style :