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Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses

Kaltsatos, V.
Published in European Journal of Pharmaceutics and Biopharmaceutics. 2000, vol. 49, no. 1, p. 27-33
Abstract Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.
Keywords FluorideDental cariesSustained delivery systemsAdhesionSalivary ¯uoride concentrationsLocal drug delivery
PMID: 10613924
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VIVIEN CASTIONI, Nathalie Nadine et al. Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses. In: European Journal of Pharmaceutics and Biopharmaceutics, 2000, vol. 49, n° 1, p. 27-33. https://archive-ouverte.unige.ch/unige:84859

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Deposited on : 2016-06-30

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