Scientific article

Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 49, no. 1, p. 27-33
Publication date2000

Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.

  • Fluoride
  • Dental caries
  • Sustained delivery systems
  • Adhesion
  • Salivary ¯uoride concentrations
  • Local drug delivery
Citation (ISO format)
VIVIEN CASTIONI, Nathalie Nadine et al. Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses. In: European journal of pharmaceutics and biopharmaceutics, 2000, vol. 49, n° 1, p. 27–33. doi: 10.1016/s0939-6411(99)00041-7
Main files (1)
Article (Published version)
ISSN of the journal0939-6411

Technical informations

Creation06/08/2016 1:38:00 PM
First validation06/08/2016 1:38:00 PM
Update time03/15/2023 12:30:07 AM
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