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Scientific article
English

Contribution of lipid components to the permeability barrier of oral mucosa

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 44, no. 2, p. 107-120
Publication date1997
Abstract

The aim of this paper is to review the lipid composition of different regions of the oral mucosa, bearing in mind that, in general, molecular diffusion occurs through the intercellular lipids. Lipid content and organization is described to explain the permeability differences between keratinized and nonkeratinized tissues. Some of the thermotropic and lyotropic transitions observed in simple lipid model systems, such as liposomes, are also taken into consideration, in an attempt to explain the contribution of each lipid class to the permeability barrier.

Keywords
  • Lipids
  • Phase transition
  • Polymorphism
  • Oral mucosa
  • Permeation enhancers
Citation (ISO format)
GANEM-QUINTANAR, A., FALSON-RIEG, Françoise, BURI, Pierre. Contribution of lipid components to the permeability barrier of oral mucosa. In: European journal of pharmaceutics and biopharmaceutics, 1997, vol. 44, n° 2, p. 107–120. doi: 10.1016/S0939-6411(97)00080-5
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ISSN of the journal0939-6411
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