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Scientific article
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English

Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson's disease

Published inMolecular neurodegeneration, vol. 11, 12
Publication date2016
Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has been established as a highly effective symptomatic therapy for Parkinson's disease (PD). An intriguing biological aspect related to the DBS procedure is that a temporary contact establishes between surgical instruments and the surrounding brain tissue. In this exploratory study, we took advantage of this unique context to harvest brain material adhering to the stylet routinely used during surgery, and to examine the biological value of these samples, here referred to as "brain tissue imprints" (BTIs).

Citation (ISO format)
ZACCARIA, Affif et al. Deep brain stimulation-associated brain tissue imprints: a new in vivo approach to biological research in human Parkinson’s disease. In: Molecular neurodegeneration, 2016, vol. 11, p. 12. doi: 10.1186/s13024-016-0077-4
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ISSN of the journal1750-1326
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Creation06/23/2016 10:58:00 AM
First validation06/23/2016 10:58:00 AM
Update time03/15/2023 12:29:56 AM
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