en
Scientific article
Open access
English

Drug Pricing Evolution in Hepatitis C

Published inPloS one, vol. 11, no. 6, e0157098
Publication date2016
Abstract

We aimed to determine the association between the stepwise increase in the sustained viral response (SVR) and Swiss and United States (US) market prices of drug regimens for treatment-naive, genotype 1 chronic hepatitis C virus (HCV) infection in the last 25 years. We identified the following five steps in the development of HCV treatment regimens: 1) interferon (IFN)-α monotherapy in the early '90s, 2) IFN-α in combination with ribavirin (RBV), 3) pegylated (peg) IFN-α in combination with RBV, 4) the first direct acting antivirals (DAAs) (telaprevir and boceprevir) in combination with pegIFN-α and RBV, and 5) newer DAA-based regimens, such as sofosbuvir (which is or is not combined with ledipasvir) and fixed-dose combination of ritonavir-boosted paritaprevir and ombitasvir in combination with dasabuvir.

Citation (ISO format)
VERNAZ-HEGI, Nathalie et al. Drug Pricing Evolution in Hepatitis C. In: PloS one, 2016, vol. 11, n° 6, p. e0157098. doi: 10.1371/journal.pone.0157098
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Article (Published version)
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ISSN of the journal1932-6203
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