en
Scientific article
English

Prevention of the sticking tendency of floating minitablets filled into hard gelatin capsules

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 43, no. 2, p. 165-171
Publication date1997
Abstract

Hydrophillic minimatrices filled into hard gelatin capsules should be able to disperse and float on the contents of the stomach. However, these floating minitablets exhibit a strong tendency to adhere to one another due to the gelatin capsule shell and to the earlier hydration of the minitablets. Two different procedures were investigated to circumvent this problem: (i) addition of a protective filler excipient into the capsule; and (ii) coating the minitablets. For this latter approach, the type and amount of coating agent and the presence of coating additives were assessed. The degree of dispersion of the minitablets was described using an equation based on the actual area generated by the individual or aggregated minitablets upon contact with the dissolution medium. We demonstrate that it is possible to prevent floating minitablets from aggregating in vitro by using either a protective filler or a polymeric coating insoluble in gastric juice but permeable and swellable.

Keywords
  • Multiple-unit dosage form
  • Minitablets
  • Floating dosage form
  • Hard gelatin capsule
  • Hydrophilic matrix
  • Film coating
  • Protective filler
Citation (ISO format)
ROUGE, Nathalie et al. Prevention of the sticking tendency of floating minitablets filled into hard gelatin capsules. In: European journal of pharmaceutics and biopharmaceutics, 1997, vol. 43, n° 2, p. 165–171. doi: 10.1016/S0939-6411(96)00003-3
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ISSN of the journal0939-6411
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