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Trans-scleral diffusion of triamcinolone acetonide

Mora, Paolo
Eperon, Simone
Sagodira, Serge
Breton, Pascal
Guex-Crosier, Yan
Published in Current Eye Research. 2005, vol. 30, no. 5, p. 355-361
Abstract PURPOSE: To assess ex vivo human scleral permeability to triamcinolone acetonide (TA). METHODS: The experiments were carried out using scleral samples and a Franz-type vertical diffusion cell. A suspension containing TA was prepared and placed in the donor chamber. The concentration of TA in the receptor chamber was measured by high-performance liquid chromatography (HPLC) assay and expressed as a percentage relative to TA concentration dissolved in the donor chamber. Control experiments using a commercial TA suspension were performed. RESULTS: TA (+/-SEM) dissolved in the donor suspension was 10.69 +/- 1.28 microg/ml. The diffusion rate of TA varied from 30% after 1 day to 72% after 4 days, after which equilibrium was reached. The human scleral permeability coefficient (P(s) +/- SEM) was 1.47+/- 0.17 x 10(- 5) cm/s. CONCLUSIONS: TA crossed human sclera. The mean amount of drug retained in the sclera increased with time, 4 days being necessary to equilibrate the unidirectional flux. The TA permeability coefficient was comparable to that of other corticosteroids.
Keywords HumanPermeability coefficientScleral diffusionTriamcinolone
PMID: 16020266
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MORA, Paolo et al. Trans-scleral diffusion of triamcinolone acetonide. In: Current eye research, 2005, vol. 30, n° 5, p. 355-361. doi: 10.1080/02713680590934094 https://archive-ouverte.unige.ch/unige:84785

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Deposited on : 2016-06-28

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