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Title

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex

Authors
Gyurkovics, Henrik
Schedl, Paul
Published in EMBO Journal. 1993, vol. 12, no. 3, p. 1087-1097
Abstract An extremely large cis-regulatory region generates the parasegment-specific expression patterns of the homeotic genes in the bithorax complex. We present evidence supporting the idea that this cis-regulatory region is subdivided into independent cis-regulatory domains. We describe a Ubx-lacZ transposon which is inserted into one of these domains, iab-7. The PS12-specific pattern of LacZ expression from this reporter indicates that it is subject to the control of the iab-7 cis-regulatory domain, but is protected from the effects of adjacent regulatory domains. Protection on the proximal side appears to be provided by the Fab-7 boundary element. Deletion of this boundary results in the ectopic activation of iab-7 in PS11 (where the iab-6 cis-regulatory domain normally functions). We show that the Fab-7 boundary, like other boundaries, has an unusual chromatin structure.
Keywords Cis-regulatoryDomain/chromatin/domainBoundary/Drosophila/homeotic
Identifiers
PMID: 8384551
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GALLONI, Mireille et al. The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex. In: EMBO Journal, 1993, vol. 12, n° 3, p. 1087-1097. https://archive-ouverte.unige.ch/unige:84782

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