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Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone

Kauffenstein, Gilles
Tamareille, Sophie
Prunier, Fabrice
Roy, Charlotte
Ayer, Audrey
Toutain, Bertrand
Billaud, Marie
Isakson, Brant E
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2016, vol. 36, p. 1598-1606
Abstract Myogenic tone (MT) of resistance arteries ensures autoregulation of blood flow in organs and relies on the intrinsic property of smooth muscle to contract in response to stretch. Nucleotides released by mechanical strain on cells are responsible for pleiotropic vascular effects, including vasoconstriction. Here, we evaluated the contribution of extracellular nucleotides to MT.
Keywords MyocytesSmooth muscleMyosin light chainsNucleotidesPurinoceptor P2Y6RhoA GTP-binding protein
PMID: 27255725
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Research group L'athérosclérose (665)
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KAUFFENSTEIN, Gilles et al. Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, vol. 36, p. 1598-1606. doi: 10.1161/ATVBAHA.116.307739 https://archive-ouverte.unige.ch/unige:84647

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Deposited on : 2016-06-20

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