Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands

Palais, Laetitia; Alexakis, Alexandre

doi:10.1016/j.tetasy.2009.11.016

Scientific article

English

Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands

ContributorsPalais, Laetitia; Alexakis, Alexandre

Published inTetrahedron: asymmetry, vol. 20, no. 24, p. 2866-2870

Publication date2009

Abstract

Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee's up to 86%).

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

PALAIS, Laetitia, ALEXAKIS, Alexandre. Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands. In: Tetrahedron: asymmetry, 2009, vol. 20, n° 24, p. 2866–2870. doi: 10.1016/j.tetasy.2009.11.016

Article (Published version)

Identifiers

PID : unige:8459
DOI : 10.1016/j.tetasy.2009.11.016

Additional URL for this publicationhttp://linkinghub.elsevier.com/retrieve/pii/S0957416609008519

Journal ISSN0957-4166

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Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands

Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee's up to 86%).

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