Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses

Loi, Monica; Müller, Anne; Steinbach, Karin; Niven, Jennifer; Barreira da Silva, Rosa; Paul, Petra; Ligeon, Laure-Anne; Caruso, Assunta; Albrecht, Randy A; Becker, Andrea C; Annaheim, Nicolas; Nowag, Heike; Dengjel, Jörn; García-Sastre, Adolfo; Merkler, Doron; Münz, Christian; Gannagé, Monique

doi:10.1016/j.celrep.2016.04.002

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Title		Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses
Authors		Loi, Monica Müller, Anne Steinbach, Karin Niven, Jennifer Barreira da Silva, Rosa Paul, Petra Ligeon, Laure-Anne Caruso, Assunta Albrecht, Randy A Becker, Andrea C Annaheim, Nicolas Nowag, Heike Dengjel, Jörn García-Sastre, Adolfo Merkler, Doron Münz, Christian Gannagé, Monique show all authors [1 - 17]
Published in		Cell reports. 2016, vol. 15, no. 5, p. 1076-87
Abstract		The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation.
Identifiers		DOI: 10.1016/j.celrep.2016.04.002 PMID: 27117419
Full text		Article (Accepted version) (2.6 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		La Sclérose en plaques (908)
Citation (ISO format)		LOI, Monica et al. Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses. In: Cell Reports, 2016, vol. 15, n° 5, p. 1076-87. doi: 10.1016/j.celrep.2016.04.002 https://archive-ouverte.unige.ch/unige:84462