

![]() |
Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses |
|
Authors | ![]() | |
Published in | Cell reports. 2016, vol. 15, no. 5, p. 1076-87 | |
Abstract | The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation. | |
Identifiers | PMID: 27117419 | |
Full text | ||
Structures | ||
Research group | La Sclérose en plaques (908) | |
Citation (ISO format) | LOI, Monica et al. Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses. In: Cell Reports, 2016, vol. 15, n° 5, p. 1076-87. doi: 10.1016/j.celrep.2016.04.002 https://archive-ouverte.unige.ch/unige:84462 |