Scientific article
Open access

Redox modulation of STIM-ORAI signaling

Published inCell calcium, vol. 60, no. 2, p. 142-152
Publication date2016

STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders. Other isoforms-STIM1L, STIM2, ORAI2 and ORAI3 exhibit varied expression levels in different cell types along with several other interaction partners and thereby play different roles to facilitate, regulate and fine-tune the calcium entry. STIM proteins convey the Ca(2+) store-depletion message to the PM and thereby participate in refilling of the ER by physically interacting with the Ca(2+)-selective ORAI channels at the PM. STIM and ORAI are exposed to oxidative modifications in the ER, the cytosol, and at the cell surface, and redox-mediated alterations in STIM/ORAI coupling might contribute to autoimmune disorders and cancer progression. This review discusses the redox reactivity of cysteine residues in STIM and ORAI isoforms, focusing on the oxidative modifications of STIM and ORAI proteins by which STIM-ORAI signaling can be modulated.

  • STIM
  • ORAI
  • CRAC
  • Store-operated calcium entry
  • Redox
  • Hypoxia
  • ROS
Citation (ISO format)
BHARDWAJ, Rajesh, HEDIGER, Matthias A, DEMAUREX, Nicolas. Redox modulation of STIM-ORAI signaling. In: Cell calcium, 2016, vol. 60, n° 2, p. 142–152. doi: 10.1016/j.ceca.2016.03.006
Main files (1)
Article (Published version)
ISSN of the journal0143-4160

Technical informations

Creation04/19/2016 6:06:00 PM
First validation04/19/2016 6:06:00 PM
Update time03/15/2023 12:27:01 AM
Status update03/15/2023 12:27:01 AM
Last indexation08/30/2023 11:54:11 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack