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Redox modulation of STIM-ORAI signaling

Bhardwaj, Rajesh
Hediger, Matthias A
Published in Cell Calcium. 2016, vol. 60, no. 2, p. 142-152
Abstract STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders. Other isoforms-STIM1L, STIM2, ORAI2 and ORAI3 exhibit varied expression levels in different cell types along with several other interaction partners and thereby play different roles to facilitate, regulate and fine-tune the calcium entry. STIM proteins convey the Ca(2+) store-depletion message to the PM and thereby participate in refilling of the ER by physically interacting with the Ca(2+)-selective ORAI channels at the PM. STIM and ORAI are exposed to oxidative modifications in the ER, the cytosol, and at the cell surface, and redox-mediated alterations in STIM/ORAI coupling might contribute to autoimmune disorders and cancer progression. This review discusses the redox reactivity of cysteine residues in STIM and ORAI isoforms, focusing on the oxidative modifications of STIM and ORAI proteins by which STIM-ORAI signaling can be modulated.
Keywords STIMORAICRACStore-operated calcium entryRedoxHypoxiaROS
PMID: 27041216
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Article (Published version) (960 Kb) - public document Free access
Research group Signaux intracellulaires (210)
Project FNS: 31003A_149566
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BHARDWAJ, Rajesh, HEDIGER, Matthias A, DEMAUREX, Nicolas. Redox modulation of STIM-ORAI signaling. In: Cell Calcium, 2016, vol. 60, n° 2, p. 142-152. https://archive-ouverte.unige.ch/unige:84444

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Deposited on : 2016-06-13

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