Background Abscesses located in the cesarean-section (CS) induced isthmoceles are rarely encountered and are usually treated surgically, mostly by hysterectomy. Case description We here report the case of a 40-year-old primiparous woman presenting a symptomatic abscess in the isthmocele 10 years after a CS. She was treated by antibiotics and was closely monitored by clinical evaluation, ultrasonography, and pelvic magnetic resonance imaging. This treatment led to complete resolution of symptoms and a disappearance of the abscess at imagery. Conclusion Our report shows that a conservative medical management of isthmocele abscesses can be an effective approach in women wishing to preserve their uterus.