UNIGE document Scientific Article - Case report
previous document  unige:84412  next document
add to browser collection

Acute respiratory distress syndrome in a patient with primary myelofibrosis after ruxolitinib treatment discontinuation

Published in International Journal of Hematology. 2014, vol. 100, no. 5, p. 498-501
Abstract Ruxolitinib is a Janus kinase (JAK) inhibitor used for the treatment of myelofibrosis with demonstrated efficacy for the alleviation of disease-related symptoms and splenomegaly. Anemia and thrombocytopenia are the main secondary effects. However, there are case reports of rare but serious adverse events following drug withdrawal. We present a case of a 76-year-old man diagnosed with primary myelofibrosis who presented with constitutional symptoms and symptomatic splenomegaly. Ruxolitinib was started (15 mg twice daily) and his disease-related symptoms disappeared. Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia. Ruxolitinib was stopped and corticosteroid treatment (prednisone 1 mg/kg/day) was started to avoid a cytokine-rebound reaction. The patient then developed fever, chills, a biological inflammatory syndrome, and an acute respiratory disease syndrome. Full workup excluded an infection and we concluded that ruxolitinib withdrawal syndrome was the likely cause. Continued treatment with corticosteroids, as well as oxygen supply and continuous positive airway pressure, allowed an alleviation of his symptoms. This case report describes acute respiratory distress syndrome as another potential complication of ruxolitinib withdrawal syndrome.
Keywords AgedAnemia/chemically inducedHumansJanus Kinases/antagonists & inhibitorsMalePrimary Myelofibrosis/complications/diagnosis/drug therapyProtein Kinase Inhibitors/adverse effects/therapeutic usePyrazoles/adverse effects/therapeutic useRadiography, ThoracicRespiratory Distress Syndrome, Adult/diagnosis/etiologyThrombocytopenia/chemically inducedTomography, X-Ray Computed
PMID: 25034748
Full text
Article (Published version) (460 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
(ISO format)
BEAUVERD, Yan, SAMII, Kaveh. Acute respiratory distress syndrome in a patient with primary myelofibrosis after ruxolitinib treatment discontinuation. In: International Journal of Hematology, 2014, vol. 100, n° 5, p. 498-501. doi: 10.1007/s12185-014-1628-5 https://archive-ouverte.unige.ch/unige:84412

371 hits

0 download


Deposited on : 2016-06-10

Export document
Format :
Citation style :