Scientific article

Plasmonic Tipless Pyramid Arrays for Cell Poration

Published inNano letters, vol. 15, no. 7, p. 4461-4466
Publication date2015

Improving the efficiency, cell survival, and throughput of methods to modify and control the genetic expression of cells is of great benefit to biology and medicine. We investigate, both computationally and experimentally, a nanostructured substrate made of tipless pyramids for plasmonic-induced transfection. By optimizing the geometrical parameters for an excitation wavelength of 800 nm, we demonstrate a 100-fold intensity enhancement of the electric near field at the cell–substrate contact area, while the low absorption typical for gold is maintained. We demonstrate that such a substrate can induce transient poration of cells by a purely optically induced process.

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Citation (ISO format)
COURVOISIER, Sébastien et al. Plasmonic Tipless Pyramid Arrays for Cell Poration. In: Nano letters, 2015, vol. 15, n° 7, p. 4461–4466. doi: 10.1021/acs.nanolett.5b01697
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Article (Published version)
ISSN of the journal1530-6984

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