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Functionalized bismuth ferrite harmonic nanoparticles for cancer cells labeling and imaging

Passemard, Solène
Sonego, Giona
Schneiter, Guillaume Stéphane
Juillerat-Jeanneret, Lucienne
Gerber-Lemaire, Sandrine
Published in Journal of Nanoparticle Research. 2015, vol. 17, no. 10
Abstract Bismuth ferrite (BFO) harmonic nanoparticles (NPs) display high nonlinear optical efficiency and excellent biocompatibility profile which make them attractive for the development of diagnostic applications as contrast agents. In this study, we present a general method for the functionalization of this material with chemical ligands targeting cancer molecular biomarkers. In particular, a conjugation protocol based on click reaction between alkynyl-containing targeting ligands and poly(ethylene glycol)-coated BFO NPs (67.7 nm) displaying surface reactive azido groups was developed. Copper-free click reaction allowed fast and efficient conjugation of a covalent inhibitor of prolyl-specific endopeptidases to coated BFO NPs. The ability of these functionalized nanomaterials (134.2 nm) to act as imaging probes for cancer cells was demonstrated by the selective labeling of human lung cancer cells.
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Other version: http://link.springer.com/10.1007/s11051-015-3218-8
Research group Groupe Wolf
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PASSEMARD, Solène et al. Functionalized bismuth ferrite harmonic nanoparticles for cancer cells labeling and imaging. In: Journal of Nanoparticle Research, 2015, vol. 17, n° 10. https://archive-ouverte.unige.ch/unige:84333

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Deposited on : 2016-06-08

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