en
Scientific article
English

Role of matrix metalloproteinases in animal models of ischemic stroke

Published inCurrent vascular pharmacology, vol. 13, no. 2, p. 161-166
Publication date2015
Abstract

Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral injury. In particular, MMP-mediated alterations lead to blood-brain barrier (BBB) leakage, cerebral edema, hemorrhage, leukocyte infiltration and progressive inflammatory reactions underlying brain tissue loss. In addition, MMPs have been also shown to play critical activities during the repair phases of cerebral ischemia, particularly during angiogenesis and reestablishment of cerebral blood flow. The aim of this narrative review is to elucidate the mechanisms by which MMPs may provide detrimental and/or beneficial effects during the post-stroke injury and repair phases in animal models.

Citation (ISO format)
LENGLET, Sébastien, MONTECUCCO, Fabrizio, MACH, François. Role of matrix metalloproteinases in animal models of ischemic stroke. In: Current vascular pharmacology, 2015, vol. 13, n° 2, p. 161–166. doi: 10.2174/15701611113116660161
Identifiers
ISSN of the journal1570-1611
469views
0downloads

Technical informations

Creation2015/11/24 12:13:00
First validation2015/11/24 12:13:00
Update time2023/03/15 00:26:00
Status update2023/03/15 00:26:00
Last indexation2024/01/16 21:00:06
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack