Scientific article

Update on the role of neutrophils in atherosclerotic plaque vulnerability

Published inCurrent drug targets, vol. 16, no. 4, p. 321-333
Publication date2015

Atherosclerosis is the main pathophysiological process underlying acute cardiovascular diseases. Life-threatening conditions, such as myocardial infarction and ischemic stroke, are provoked by the sudden rupture of vulnerable atherosclerotic plaques, characterized by thin, highly inflamed and collagen-poor fibrous cap. Whereas both innate and adaptive inflammation progressively emerged as driving force of this processes, less is known about the involvement of neutrophils (PMNs). Advances in laboratory techniques during the last two decades disclosed that PMNs play a crucial role in promoting plaque vulnerability by the release of different enzymes, such as gelatinases (matrix metalloproteinases) collagenases, elastase and myeloperoxidase. Accordingly, circulating levels of PMNs and their products have been investigated as potential markers of plaque instability in both primary and secondary prevention on cardiovascular diseases. In addition, the development of different classes of drugs targeting PMNs activation is emerging as an interesting field of research. This narrative review will provide an update on the role of PMNs in promoting plaque vulnerability also discussing the potential effects of therapeutic strategies targeting PMN on plaque vulnerability.

Citation (ISO format)
CARBONE, Federico, MACH, François, MONTECUCCO, Fabrizio. Update on the role of neutrophils in atherosclerotic plaque vulnerability. In: Current drug targets, 2015, vol. 16, n° 4, p. 321–333. doi: 10.2174/1389450115666141110093013
ISSN of the journal1389-4501

Technical informations

Creation11/24/2015 12:15:00 PM
First validation11/24/2015 12:15:00 PM
Update time03/15/2023 12:25:59 AM
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