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Scientific article
English

Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury

Published inThe journal of sexual medicine, vol. 12, no. 2, p. 289-302
Publication date2015
Abstract

Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development of erectile dysfunction (ED), while treatment with angiotensin-(1-7) improves penile erection. However, the expression and function of ACE2 in erectile tissues have never been investigated.

Keywords
  • Angiotensin I/metabolism
  • Animals
  • Apolipoproteins E
  • Diminazene/analogs & derivatives/pharmacology
  • Down-Regulation
  • Erectile Dysfunction/drug therapy/etiology/physiopathology
  • Hypercholesterolemia/complications
  • Male
  • Mice
  • Mice, Knockout
  • NADPH Oxidase/metabolism
  • Nitric Oxide/metabolism
  • Nitric Oxide Synthase Type I/metabolism
  • Nitric Oxide Synthase Type III/metabolism
  • Penile Erection
  • Penis/physiopathology
  • Peptide Fragments/metabolism
  • Peptidyl-Dipeptidase A/drug effects/metabolism
  • Reactive Oxygen Species/metabolism
Citation (ISO format)
FRAGA-SILVA, Rodrigo A et al. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. In: The journal of sexual medicine, 2015, vol. 12, n° 2, p. 289–302. doi: 10.1111/jsm.12757
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1743-6095
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Creation11/24/2015 12:08:00 PM
First validation11/24/2015 12:08:00 PM
Update time03/15/2023 12:25:59 AM
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