Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury

Fraga-Silva, Rodrigo A; Costa-Fraga, Fabiana P; Montecucco, Fabrizio; Sturny, Mikael; Faye, Younoss; Mach, François; Pelli, Graziano; Shenoy, Vinayak; da Silva, Rafaela F; Raizada, Mohan K; Santos, Robson A S; Stergiopulos, Nikolaos

doi:10.1111/jsm.12757

Scientific article

English

Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury

ContributorsFraga-Silva, Rodrigo A; Costa-Fraga, Fabiana P; Montecucco, Fabrizio; Sturny, Mikael; Faye, Younoss; Mach, François; Pelli, Graziano; Shenoy, Vinayak; da Silva, Rafaela F; Raizada, Mohan K; Santos, Robson A S; Stergiopulos, Nikolaos

Published inThe journal of sexual medicine, vol. 12, no. 2, p. 289-302

Publication date2015

Abstract

Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development of erectile dysfunction (ED), while treatment with angiotensin-(1-7) improves penile erection. However, the expression and function of ACE2 in erectile tissues have never been investigated.

Keywords

Angiotensin I/metabolism
Animals
Apolipoproteins E
Diminazene/analogs & derivatives/pharmacology
Down-Regulation
Erectile Dysfunction/drug therapy/etiology/physiopathology
Hypercholesterolemia/complications
Male
Mice
Mice, Knockout
NADPH Oxidase/metabolism
Nitric Oxide/metabolism
Nitric Oxide Synthase Type I/metabolism
Nitric Oxide Synthase Type III/metabolism
Penile Erection
Penis/physiopathology
Peptide Fragments/metabolism
Peptidyl-Dipeptidase A/drug effects/metabolism
Reactive Oxygen Species/metabolism

Affiliation entities

Research groups

Athérosclérose (591)

Citation (ISO format)

FRAGA-SILVA, Rodrigo A et al. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. In: The journal of sexual medicine, 2015, vol. 12, n° 2, p. 289–302. doi: 10.1111/jsm.12757

Article (Published version)

Identifiers

PID : unige:84320
DOI : 10.1111/jsm.12757
PMID : 25411084

Journal ISSN1743-6095

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Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury

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