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Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury

Fraga-Silva, Rodrigo A
Costa-Fraga, Fabiana P
Sturny, Mikael
Faye, Younoss
Shenoy, Vinayak
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Published in The journal of sexual medicine. 2015, vol. 12, no. 2, p. 289-302
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development of erectile dysfunction (ED), while treatment with angiotensin-(1-7) improves penile erection. However, the expression and function of ACE2 in erectile tissues have never been investigated.
Keywords Angiotensin I/metabolismAnimalsApolipoproteins EDiminazene/analogs & derivatives/pharmacologyDown-RegulationErectile Dysfunction/drug therapy/etiology/physiopathologyHypercholesterolemia/complicationsMaleMiceMice, KnockoutNADPH Oxidase/metabolismNitric Oxide/metabolismNitric Oxide Synthase Type I/metabolismNitric Oxide Synthase Type III/metabolismPenile ErectionPenis/physiopathologyPeptide Fragments/metabolismPeptidyl-Dipeptidase A/drug effects/metabolismReactive Oxygen Species/metabolism
PMID: 25411084
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Research group L'athérosclérose et ses complications cliniques (591)
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FRAGA-SILVA, Rodrigo A et al. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. In: The journal of sexual medicine, 2015, vol. 12, n° 2, p. 289-302. doi: 10.1111/jsm.12757 https://archive-ouverte.unige.ch/unige:84320

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Deposited on : 2016-06-08

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