Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin

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Title		Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin
Authors		Mattenberger, Yves Benoît James, Dominic Martinou, Jean-Claude
Published in		FEBS Letters. 2003, vol. 538, no. 1-3, p. 53-59
Abstract		Mitochondrial fusion is a poorly characterized process which has mainly been studied in yeast and Drosophila but is thought to occur in all eukaryotes. Until now, there was only indirect evidence to support such a process in mammalian cells. In this study, using a cell fusion system, we found that mitochondrial fusion occurs rapidly in mammalian cells and is completed in less than 24 h. We report that the fusion of mitochondria requires an intact mitochondrial inner membrane potential but is independent of a functional cytoskeleton.
Keywords		Mitochondrial fusion — Membrane potential — Actin — Tubulin
Identifiers		DOI: 10.1016/s0014-5793(03)00124-8 PMID: 12633852
Full text		Article (Published version) (405 Kb) - Limited access to UNIGE
Structures		Faculté des sciences / Section de biologie / Département de biologie cellulaire
Citation (ISO format)		MATTENBERGER, Yves Benoît, JAMES, Dominic, MARTINOU, Jean-Claude. Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin. In: FEBS Letters, 2003, vol. 538, n° 1-3, p. 53-59. doi: 10.1016/s0014-5793(03)00124-8 https://archive-ouverte.unige.ch/unige:84288

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Deposited on : 2016-06-07

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