en
Scientific article
English

Endocytosis and signaling cascades: a close encounter

Published inFEBS letters, vol. 498, no. 2-3, p. 190-196
Publication date2001
Abstract

Internalization of receptors and other cell surface components is well known to occur via clathrin-mediated endocytosis, although other less well characterized pathways are also involved. Internalized receptors are then delivered to early endosomes, where they are sorted to be recycled back to the plasma membrane for reutilization or transported to late endosomes/lysosomes for degradation. Endocytosis has long been considered as a constitutive, housekeeping function of animal cells that occurs independently of the cellular environment in contrast to regulated secretion. Here, we will discuss recent studies that are uncovering the existence of cross-talk between signaling molecules and components of the transport machinery, indicating that endocytosis can be modulated by signaling pathways.

Keywords
  • Signal transduction
  • Tra¤ff
  • Rab protein
  • Phosphoinositide
  • Growth factor
  • Clathrin
  • Actin
  • FYVE protein
Citation (ISO format)
CAVALLI, Valeria Maria, FELBERBAUM-CORTI, Michela, GRUENBERG, Jean. Endocytosis and signaling cascades: a close encounter. In: FEBS letters, 2001, vol. 498, n° 2-3, p. 190–196. doi: 10.1016/s0014-5793(01)02484-x
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ISSN of the journal0014-5793
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