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Title

CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells

Authors
Bellec, Jessica
Anegon, Ignacio
Published in Current gene therapy. 2015, vol. 15, no. 5, p. 447-459
Abstract Polarized airway epithelial cell cultures modelling Cystic Fibrosis Transmembrane conductance Regulator (CFTR) defect are crucial for CF and biomedical research. RNA interference has proven its value to generate knockdown models for various pathologies. More recently, genome editing using CRISPR-Cas9 artificial endonuclease was a valuable addition to the toolbox of gene inactivation.
Keywords CFTRCRISPR-Cas9Cystic fibrosisLentiviral vectorPrimary cellsRNA interference
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PMID: 26264708
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Research group Mucoviscidose et jonctions GAP (229)
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BELLEC, Jessica et al. CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. In: Current gene therapy, 2015, vol. 15, n° 5, p. 447-459. https://archive-ouverte.unige.ch/unige:84234

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Deposited on : 2016-06-06

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