UNIGE document Scientific Article
previous document  unige:84214  next document
add to browser collection

Atherosclerosis at arterial bifurcations: evidence for the role of haemodynamics and geometry

Morbiducci, Umberto
Kok, Annette M
Stone, Peter H
Steinman, David A
Wentzel, Jolanda J
Published in Thrombosis and Haemostasis. 2016, vol. 115, no. 3, p. 484-92
Abstract Atherosclerotic plaques are found at distinct locations in the arterial system, despite the exposure to systemic risk factors of the entire vascular tree. From the study of arterial bifurcation regions, emerges ample evidence that haemodynamics are involved in the local onset and progression of the atherosclerotic disease. This observed co-localisation of disturbed flow regions and lesion prevalence at geometrically predisposed districts such as arterial bifurcations has led to the formulation of a 'haemodynamic hypothesis', that in this review is grounded to the most current research concerning localising factors of vascular disease. In particular, this review focuses on carotid and coronary bifurcations because of their primary relevance to stroke and heart attack. We highlight reported relationships between atherosclerotic plaque location, progression and composition, and fluid forces at vessel's wall, in particular shear stress and its 'easier-to-measure' surrogates, i.e. vascular geometric attributes (because geometry shapes the flow) and intravascular flow features (because they mediate disturbed shear stress), in order to give more insight in plaque initiation and destabilisation. Analogous to Virchow's triad for thrombosis, atherosclerosis must be thought of as subject to a triad of, and especially interactions among, haemodynamic forces, systemic risk factors, and the biological response of the wall.
Keywords AtherosclerosisBiomechanicsShear stressArterial bifurcationHaemodynamics
PMID: 26740210
Full text
Article (Published version) (321 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group L'athérosclérose (665)
(ISO format)
MORBIDUCCI, Umberto et al. Atherosclerosis at arterial bifurcations: evidence for the role of haemodynamics and geometry. In: Thrombosis and Haemostasis, 2016, vol. 115, n° 3, p. 484-92. https://archive-ouverte.unige.ch/unige:84214

122 hits



Deposited on : 2016-06-06

Export document
Format :
Citation style :