UNIGE document Scientific Article
previous document  unige:84213  next document
add to browser collection
Title

Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43

Authors
Christoffersen, Christina
Axelsen, Lene N
Rochemont, Viviane
show hidden authors show all authors [1 - 14]
Published in Cardiovascular Research. 2016, vol. 109, no. 3, p. 385-96
Abstract Increasing evidence points to lipoprotein composition rather than reverse cholesterol transport in the cardioprotective properties of high-density lipoproteins (HDLs). HDL binding to receptors at the surface of cardiomyocytes activates signalling pathways promoting survival, but downstream targets are largely unknown. Here, we investigate the pathways by which the sphingosine-1-phosphate (S1P) constituent of HDL limits cell death induced by cardiac ischaemia-reperfusion (I/R).
Keywords Sphingosine-1-phosphateIschaemia–reperfusion injuryConnexin43
Identifiers
PMID: 26762268
Full text
Article (Published version) (812 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups L'athérosclérose (665)
Mucoviscidose et jonctions GAP (229)
Citation
(ISO format)
MOREL, Sandrine et al. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. In: Cardiovascular Research, 2016, vol. 109, n° 3, p. 385-96. https://archive-ouverte.unige.ch/unige:84213

199 hits

2 downloads

Update

Deposited on : 2016-06-06

Export document
Format :
Citation style :