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Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43 |
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Authors | ![]() | |
Published in | Cardiovascular Research. 2016, vol. 109, no. 3, p. 385-96 | |
Abstract | Increasing evidence points to lipoprotein composition rather than reverse cholesterol transport in the cardioprotective properties of high-density lipoproteins (HDLs). HDL binding to receptors at the surface of cardiomyocytes activates signalling pathways promoting survival, but downstream targets are largely unknown. Here, we investigate the pathways by which the sphingosine-1-phosphate (S1P) constituent of HDL limits cell death induced by cardiac ischaemia-reperfusion (I/R). | |
Keywords | Sphingosine-1-phosphate — Ischaemia–reperfusion injury — Connexin43 | |
Identifiers | DOI: 10.1093/cvr/cvw004 PMID: 26762268 | |
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Structures | ||
Research groups | L'athérosclérose (665) L'athérosclérose et ses complications cliniques (591) Mucoviscidose et jonctions communicantes (229) Traits génétiques complexes (901) | |
Citation (ISO format) | MOREL, Sandrine et al. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. In: Cardiovascular Research, 2016, vol. 109, n° 3, p. 385-96. doi: 10.1093/cvr/cvw004 https://archive-ouverte.unige.ch/unige:84213 |