Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43

Morel, Sandrine; Christoffersen, Christina; Axelsen, Lene N; Montecucco, Fabrizio; Rochemont, Viviane; Frias, Miguel; Mach, François; James, Richard William; Naus, Christian C; Chanson, Marc; Lampe, Paul D; Nielsen, Morten S; Nielsen, Lars B; Kwak, Brenda

doi:10.1093/cvr/cvw004

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Title		Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43
Authors		Morel, Sandrine Christoffersen, Christina Axelsen, Lene N Montecucco, Fabrizio Rochemont, Viviane Frias, Miguel Mach, François James, Richard William Naus, Christian C Chanson, Marc Lampe, Paul D Nielsen, Morten S Nielsen, Lars B Kwak, Brenda show all authors [1 - 14]
Published in		Cardiovascular Research. 2016, vol. 109, no. 3, p. 385-96
Abstract		Increasing evidence points to lipoprotein composition rather than reverse cholesterol transport in the cardioprotective properties of high-density lipoproteins (HDLs). HDL binding to receptors at the surface of cardiomyocytes activates signalling pathways promoting survival, but downstream targets are largely unknown. Here, we investigate the pathways by which the sphingosine-1-phosphate (S1P) constituent of HDL limits cell death induced by cardiac ischaemia-reperfusion (I/R).
Keywords		Sphingosine-1-phosphate — Ischaemia–reperfusion injury — Connexin43
Identifiers		DOI: 10.1093/cvr/cvw004 PMID: 26762268
Full text		Article (Published version) (812 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		L'athérosclérose (665) L'athérosclérose et ses complications cliniques (591) Mucoviscidose et jonctions communicantes (229) Traits génétiques complexes (901)
Citation (ISO format)		MOREL, Sandrine et al. Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. In: Cardiovascular Research, 2016, vol. 109, n° 3, p. 385-96. doi: 10.1093/cvr/cvw004 https://archive-ouverte.unige.ch/unige:84213