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The Dark Side of Cell Fusion

Published in International Journal of Molecular Sciences. 2016, vol. 17, no. 5
Abstract Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.
PMID: 27136533
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Article (Published version) (885 Kb) - public document Free access
Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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BASTIDA RUIZ, Daniel, VAN HOESEN, Kylie, COHEN, Marie-Benoîte. The Dark Side of Cell Fusion. In: International Journal of Molecular Sciences, 2016, vol. 17, n° 5. https://archive-ouverte.unige.ch/unige:84151

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Deposited on : 2016-06-02

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