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The Dark Side of Cell Fusion

Contributors

Bastida Ruiz, Daniel; Van Hoesen, Kylie; Cohen, Marie-Benoîte

Published in

International journal of molecular sciences, vol. 17, no. 5

Publication date

2016

Abstract

Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BASTIDA RUIZ, Daniel, VAN HOESEN, Kylie, COHEN, Marie-Benoîte. The Dark Side of Cell Fusion. In: International journal of molecular sciences, 2016, vol. 17, n° 5. doi: 10.3390/ijms17050638

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1422-0067
591views
385downloads

Technical informations

Creation

31/05/2016 12:35:00

First validation

31/05/2016 12:35:00

Update

15/03/2023 00:24:34

Status update

15/03/2023 00:24:33

Last indexation

31/10/2024 03:32:55
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