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The Dark Side of Cell Fusion

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Published in International Journal of Molecular Sciences. 2016, vol. 17, no. 5
Abstract Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.
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PMID: 27136533
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Article (Published version) (885 Kb) - public document Free access
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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BASTIDA RUIZ, Daniel, VAN HOESEN, Kylie, COHEN, Marie-Benoîte. The Dark Side of Cell Fusion. In: International Journal of Molecular Sciences, 2016, vol. 17, n° 5. https://archive-ouverte.unige.ch/unige:84151

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Deposited on : 2016-06-02

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