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MHCII mediated antigen-presentation by lymph node stromal cells in autoimmunity and cancer

ContributorsSchlaeppi, Anjalie
Master program titleMaster en biologie, orientation libre
Defense date2016
Abstract

Lymph nodes stromal cells (LNSCs) modulate the functions of hematopoietic antigen-presenting cells (APCs) and impact T cell homeostasis. LNSCs can ectopically express peripheral tissue-restricted antigens and present them through MHCI to induce self-reactive CD8+ T cell deletion. To study their role as MHCII-restricted APCs, we used a mouse model where MHCII was abrogated in LNSCs. Aging mice developed spontaneous autoimmunity, including enhanced T cell activation, autoantibodies, and T cell infiltration in peripheral organs. Our data highlight a tolerogenic impact of MHCII-mediated self-antigen presentation by LNSCs on CD4+ T cells in autoimmunity. However, mechanisms of immune suppression can lead to pathogens or tumors escaping immune responses. A second axis of our investigations was to determine whether tumor associated LNSCs present tumor antigens through MHCII and modulate tumor specific CD4+ T cell responses. Our preliminary data indicate that tumor associated LNSCs support immunosuppression, promote tumor growth and that MHCII-tumor antigen presentation has pro-tumoral functions. Our project revealed crucial new insights about a role of antigen-presenting LNSCs in peripheral T cell tolerance, a concept that will significantly impacts strategies to modulate their function in cancer and autoimmunity.

eng
Keywords
  • Lymph node stromal cell
  • Tolerance
  • Autoimmunity
  • Cancer
Citation (ISO format)
SCHLAEPPI, Anjalie. MHCII mediated antigen-presentation by lymph node stromal cells in autoimmunity and cancer. 2016.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:84054
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Creation05/31/2016 12:03:00 PM
First validation05/31/2016 12:03:00 PM
Update time03/15/2023 12:23:56 AM
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