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Pacritinib: a new agent for the management of myelofibrosis?

McLornan, Donal P
Harrison, Claire N
Published in Expert Opinion on Pharmacotherapy. 2015, vol. 16, no. 15, p. 2381-90
Abstract Myelofibrosis (MF) is a clonal haematological disease associated with recurrent somatic gene mutations (JAK2V617F, MPL, CALR) and constitutive activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription pathway. MF is often characterised by debilitating symptoms and JAK inhibitors (JAKIs) have revolutionised available therapeutic options. Ruxolitinib, a JAK1 and 2 inhibitor, is the only currently approved agent. Several other JAKIs are undergoing evaluation in the clinical trial setting and Pacritinib , a novel JAK2 and FLT3 inhibitor, is at an advanced stage of investigation with recent completion of a Phase III trial and another ongoing.
PMID: 26389774
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BEAUVERD, Yan, MCLORNAN, Donal P, HARRISON, Claire N. Pacritinib: a new agent for the management of myelofibrosis?. In: Expert Opinion on Pharmacotherapy, 2015, vol. 16, n° 15, p. 2381-90.

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Deposited on : 2016-05-31

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