UNIGE document Doctoral Thesis
previous document  unige:8400  next document
add to browser collection
Title

Investigation of antiplasmodial compounds from various plant extracts : Argemone mexicana L. (Papaveraceae), Licania octandra (Hoffmanns. ex. Roem & Schult) Kuntze (Chrysobalanaceae) and Syzygium cumini (L.) Skeels (Myrtaceae)

Author
Director
Defense Thèse de doctorat : Univ. Genève, 2009 - Sc. 4129 - 2009/07/27
Abstract Malaria is one of the world's leading killer infectious diseases, with an estimated 300-500 million cases every year. It is caused by protozoan of the genus Plasmodium. In order to find antiplasmodial natural products, three plants were selected for bioguided isolation: Argemone mexicana, Licania octandra and Syzygium cumini. The alkaloids allocryptopine, berberine and protopine were isolated from A. mexicana traditional preparation and demonstrated to be active against P. falciparum. A quantitative NMR method was developed to determine the concentration of alkaloids in the decoction. From L. octandra hydroalcoholic leaf extract, flavonoids were isolated: myricetin and quercetin derivatives, as well as their aglycones were considered active against P. falciparum, while taxifolin and its derivative were not active. From S. cumini stem bark decoction, five compounds were isolated, including the new 3-O-methylellagic acid 3'-O-β-D-glucopyranoside. Only ellagic acid showed reduction of in vitro parasitaemia.
Keywords MalariaAntiplasmodialArgemoneSyzygiumLicaniaBerberineAllocryptopineProtopineEllagic acidNMR
Identifiers
URN: urn:nbn:ch:unige-84004
Full text
Thesis (5.1 MB) - public document Free access
Structures
Citation
(ISO format)
SIMOES AVELLO, Claudia. Investigation of antiplasmodial compounds from various plant extracts : Argemone mexicana L. (Papaveraceae), Licania octandra (Hoffmanns. ex. Roem & Schult) Kuntze (Chrysobalanaceae) and Syzygium cumini (L.) Skeels (Myrtaceae). Université de Genève. Thèse, 2009. https://archive-ouverte.unige.ch/unige:8400

570 hits

2795 downloads

Update

Deposited on : 2010-06-23

Export document
Format :
Citation style :