en
Scientific article
English

Biogenesis of transport intermediates in the endocytic pathway

Published inFEBS letters, vol. 452, no. 1-2, p. 61-66
Publication date1999
Abstract

Evidence is accumulating that membrane traffic between organelles can be achieved by different types of intermediates. Small (< 100 nm) and short-lived vesicles mediate transport from the plasma membrane or the trans-Golgi network to endosomes, and formation of these vesicles depends on specific adapter complexes. In contrast, transport from early to late endosomes is achieved by relatively large (approximately 0.5 microm), long-lived and multivesicular intermediates, and their biogenesis depends on endosomal COP-I proteins. Here, we review recent work on the formation of these different transport intermediates, and we discuss, in particular, coat proteins, sorting signals contained in cargo molecules and the emerging role of lipid in vesicle biogenesis.

Keywords
  • Adapter
  • COP protein
  • Sorting
  • Endosome
  • Multivesicular body
Citation (ISO format)
GU, Feng, GRUENBERG, Jean. Biogenesis of transport intermediates in the endocytic pathway. In: FEBS letters, 1999, vol. 452, n° 1-2, p. 61–66.
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Article (Published version)
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ISSN of the journal0014-5793
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