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Scientific article
English

Mechanisms in Endrocrinology: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Published inEuropean journal of endocrinology, vol. 174, no. 4, p. R127-R138
Publication date2016
Abstract

Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved,along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover. In turn, increasing physical activity in children with diabetes as well as good glycaemic control appears to provide some improvement of bone parameters, although robust clinical studies are still lacking. In this context, the role of osteoporosis drugs remains unknown.

Citation (ISO format)
HOUGH, F S et al. Mechanisms in Endrocrinology: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus. In: European journal of endocrinology, 2016, vol. 174, n° 4, p. R127–R138. doi: 10.1530/EJE-15-0820
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ISSN of the journal0804-4643
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Creation03/21/2016 11:36:00 AM
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