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Scientific article
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APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells

Published inClinical cancer research, vol. 21, no. 17, p. 3934-3945
Publication date2015
Abstract

The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, APO866, has been previously shown to have antileukemic activity in preclinical models, but its cytotoxicity in primary leukemia cells is frequently limited. The success of current antileukemic treatments is reduced by the occurrence of multidrug resistance, which, in turn, is mediated by membrane transport proteins, such as P-glycoprotein-1 (Pgp). Here, we evaluated the antileukemic effects of APO866 in combination with Pgp inhibitors and studied the mechanisms underlying the interaction between these two types of agents.

Citation (ISO format)
CAGNETTA, Antonia et al. APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. In: Clinical cancer research, 2015, vol. 21, n° 17, p. 3934–3945. doi: 10.1158/1078-0432.CCR-14-3023
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ISSN of the journal1078-0432
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Creation11/24/2015 11:52:00 AM
First validation11/24/2015 11:52:00 AM
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