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Calcium signalling in malaria parasites

Billker, Oliver
Published in Molecular microbiology. 2016, vol. 100, no. 3, p. 397-408
Abstract Ca(2+) is a ubiquitous intracellular messenger in malaria parasites with important functions in asexual blood stages responsible for malaria symptoms, the preceding liver-stage infection and transmission through the mosquito. Intracellular messengers amplify signals by binding to effector molecules that trigger physiological changes. The characterisation of some Ca(2+) effector proteins has begun to provide insights into the vast range of biological processes controlled by Ca(2+) signalling in malaria parasites, including host cell egress and invasion, protein secretion, motility, and cell cycle regulation. Despite the importance of Ca(2+) signalling during the life cycle of malaria parasites, little is known about Ca(2+) homeostasis. Recent findings highlighted that upstream of stage-specific Ca(2+) effectors is a conserved interplay between second messengers to control critical intracellular Ca(2+) signals throughout the life cycle. The identification of the molecular mechanisms integrating stagetranscending mechanisms of Ca(2+) homeostasis in a network of stage-specific regulator and effector pathways now represents a major challenge for a meaningful understanding of Ca(2+) signalling in malaria parasites. This article is protected by copyright. All rights reserved.
PMID: 26748879
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Research group Signalisation chez les parasites du paludisme (955)
Swiss National Science Foundation: BSSGI0_155852
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BROCHET, Mathieu, BILLKER, Oliver. Calcium signalling in malaria parasites. In: Molecular microbiology, 2016, vol. 100, n° 3, p. 397-408. doi: 10.1111/mmi.13324 https://archive-ouverte.unige.ch/unige:83917

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Deposited on : 2016-05-27

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